![]() ![]() Contactless delivery and your first delivery or pickup order is free Start shopping online now with Instacart to get your favorite products on-demand. Grapefruit is a source of vitamin C, fiber. Knudsen Family Juice, Organic, Just Grapefruit, Unsweetened delivered to you in as fast as 1 hour via Instacart or choose curbside or in-store pickup. ![]() It has also been used for other conditions, but with limited evidence. Organic fruit had a commercially preferred thinner peel, and the juice was higher in ascorbic acid and sugars and lower in nitrate and the drug interactive furanocoumarins. Grapefruit (Citrus paradisi) is a citrus fruit. Conventional fruit was better colored and higher in lycopene, and the juice was less tart, lower in the bitter principle naringin, and better accepted by the consumer panel than the organic fruit. Within each harvest season, conventional and organic whole fruits were compared for marketable qualities (fruit weight, specific gravity, peel thickness, and peel color), and juices were compared for marketable qualities (specific gravity, % juice, and color), human health-bioactive compounds (minerals, ascorbic acid, lycopene, sugars, pectin, phenols, and nitrates), and consumer taste intensity and overall acceptance. Whole grapefruits from each production system were harvested between 8 h at commercial early (November), mid- (January), and late season (March) harvest periods for three consecutive years. The aforementioned production variables common to both production systems were matched for comparison of Texas commercially grown conventional and certified organic Rio Red red-fruited grapefruit. This is due mainly to a lack of rigor in research studies matching common production variables of both production systems, such as microclimate, soil type, fertilizer elemental concentration, previous crop, irrigation source and application, plant age, and cultivar. This appears to be the first report of a single dietary constituent clinically modulating drug transport.Most claims that organic produce is better tasting and more nutritious than nonorganic (conventional) produce are largely unsubstantiated. Inherent OATP1A2 activity may be influenced by genetic factors. ![]() Naringin appears to have sufficient safety, specificity, and sensitivity to be a clinical OATP1A2 inhibitor probe. Inactivation of enteric CYP3A4 was probably not involved. Naringin most probably directly inhibited enteric OATP1A2 to decrease oral fexofenadine bioavailability. Individuals tested in both studies (n=9 of 12) had highly reproducible fexofenadine AUC with water (r(2)=0.85, P<0.001) and extent of reduction of it with grapefruit juice (r(2)=0.72, P<0.01). Fexofenadine AUCs with grapefruit juice and particulate fractions were 57% (P<0.001), 96% (not significant (NS)), and 97% (NS) of that with water, respectively. Fexofenadine area under the plasma drug concentration-time curves (AUCs) with grapefruit juice and naringin solution were 55% (P<0.001) and 75% (P<0.05) of that with water, respectively. Naringin and hesperidin's half-maximal inhibitions were 3.6 and 2.7 microM, respectively. In the other study, fexofenadine was administered with grapefruit juice, with or 2 h before aqueous suspension of the particulate fraction of juice containing known clinical inhibitors of enteric CYP3A4, but relatively low naringin concentration (34 microM), or with water. In one study, 120 mg of fexofenadine was ingested with 300 ml grapefruit juice, an aqueous solution of naringin at the same juice concentration (1,200 microM), or water. Two randomized, crossover, pharmacokinetic studies were performed clinically. About ORGANIC GRAPEFRUIT JUICE, UPC: 074682107616 ORGANIC GRAPEFRUIT JUICE, UPC: 074682107616 contain(s) 50 calories per 100 grams (3.53 ounces) price Ingredients: ORGANIC GRAPEFRUIT JUICE. Inhibition of OATP1A2 transport by flavonoids in grapefruit (naringin) and orange (hesperidin) was conducted in vitro. We showed previously that grapefruit and orange juices inhibited human enteric organic anion-transporting polypeptide (OATP)1A2 in vitro and lowered oral fexofenadine bioavailability clinically. ![]()
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